CliniCrowd Parkinson’s registry is driven by pre-clinical studies conducted by Professor Daniel Segal and Professor Ehud Gazit at Tel Aviv University in Israel and by Professor Eliezer Masliah at the University of California, San Diego. See publication
Alpha synuclein is an abundant protein in the brain especially in the presynaptic terminal of neurons. It plays a role in maintaining vesicles for the neurotransmitters in the nerve endings. Parkinson’s disease (PD) is characterized by degeneration and loss of neurons particularly those crucial for coordination of movements. According to the Michael J. Fox Foundation it is the pathological hallmark of Parkinson’s. Significant research has been done in the areas of preventing excess alpha synuclein formation or clumping and disruption of the already existing clumps.
Mannitol, a common low calorie sweetener, found by the FDA to be generally recognized as safe (GRAS) food additive (See link to FDA site and link to EFSA site.), has shown the ability to diminish alpha synuclein in the test tube, fruit flies, and mice, and improved their Parkinson’s-like symptoms. To date, several Parkinson’s patients who have read the scientific data have decided they have nothing to lose by trying Mannitol as a sweetener. Some of them have reported improvement in their Parkinson’s grade and symptoms.