Parkinson’s Disease

Revolutionizing the way Parkinson’s is treated by focusing on the cause

Want to find out if Mannitol can help Parkinson’s ?



CliniCrowd is a global community for Parkinson’s patients and those at-risk to share their experiences, treatments, and insights. The goal of the site is to provide you with science-based, safe solutions to help you manage your disease.

By joining CliniCrowd, you can easily track your disease progress and make educated decisions about which treatments work best for you. The wisdom of the crowd will be used to test whether treatments are effective enough to achieve desired outcomes while allowing you to compare your status with your community members.


Sign in to CliniCrowd website
click here  to Sign in
Fill out the Parkinson’s Initial Registry
Main menu >> Registries or click here (once you are logged in)
Get relevant information about Mannitol
Once you submit the registry, you will be directed to a page with detailed information such as; where to purchase, recommended dosage according to research, usage, side affects
and more
Fill out the Parkinson’s Follow Up Registry on a monthly basis
go to Main menu >> Registries or click here


CliniCrowd Parkinson’s registry is driven by pre-clinical studies conducted by Professor Daniel Segal and Professor Ehud Gazit at Tel Aviv University in Israel and by Professor Eliezer Masliah at the University of California, San Diego. See publication

Alpha synuclein is an abundant protein in the brain especially in the presynaptic terminal of neurons. It plays a role in maintaining vesicles for the neurotransmitters in the nerve endings. Parkinson’s disease (PD) is characterized by degeneration and loss of neurons particularly those crucial for coordination of movements. According to the Michael J. Fox Foundation it is the pathological hallmark of Parkinson’s. Significant research has been done in the areas of preventing excess alpha synuclein formation or clumping and disruption of the already existing clumps.

Mannitol, a common low calorie sweetener, found by the FDA to be generally recognized as safe (GRAS) food additive (See link to FDA site and link to EFSA site.), has shown the ability to diminish alpha synuclein in the test tube, fruit flies, and mice, and improved their Parkinson’s-like symptoms. To date, several Parkinson’s patients who have read the scientific data have decided they have nothing to lose by trying Mannitol as a sweetener. Some of them have reported improvement in their Parkinson’s grade and symptoms.


We’d like to invite you to join the Crowd to see if you, too, can benefit from Mannitol.

Click below to enter the registry: first time and returning participants



Slide FIGHTING PARKINSON'S DISEASE "I experiemced am imrovement in a month... the process takes and needs patience..." Parkinson's Dan, taking Mannitol since April 7, 2016 JOIN US Slide FIGHTING PARKINSON'S DISEASE “After a few weeks of Mannitol consumption (and a better sleep), I started feeling a positive change in my level of energy and ability to do things – and this, I believe, is the biggest gain” Parkinson's E, Age 46, diagnosed at age 39, taking Mannitol since July 1, 2016 JOIN US Slide FIGHTING PARKINSON'S DISEASE “At 2 months, I began to notice that my typing was improving. My arms became more steady. This might sound insignificant, but it was a powerful change to me. Into month 3 & 4, I started to notice that my left arm was able to extend without shaking as much as usual. I am holding a coffee cup, no shaking. I am holding my toothbrush, shaking, but better than before. My optimism is beginning to grow. Month 5, I am noticing my walking is becoming more normalized. Here I am at 6 months and although subtle, the changes are exciting.” Parkinson's D, taking Mannitol since January, 2017 JOIN US Slide FIGHTING PARKINSON'S DISEASE “I was more than pleasantly surprised at the positive effect of Mannitol on my Parkinson’s symptoms. Within a few weeks, my walking improved tremendously. Although there have been some setbacks – we went through a very difficult period in which I was living on adrenaline – my off times still not as bad as they were before, and during my on times, I forget that I was ever diagnosed as having Parkinson’s.” Parkinson's Debbie, taking Mannitol since Aug 11, 2016 JOIN US Slide FIGHTING PARKINSON'S DISEASE “Give time time, patience ..” Parkinson's David, taking Mannitol since Sep 1, 2016 JOIN US Slide FIGHTING PARKINSON'S DISEASE “From the outset, I felt good things happening. My sleep improved. My sense of smell was returning. Yes, it was gradual process. It took time. At the beginning there were ups and downs but, for the first time in years, I felt something healthy happening to me. It was not a simple process. Myself and Parkinson’s? We are closely intertwined. It is difficult for both of us to let go. But, just as Parkinson’s manifests itself differently in other people, Mannitol does too” Parkinson's A.D. taking Mannitol since June 17, 2016 JOIN US Slide FIGHTING PARKINSON'S DISEASE Rafi Eldor, Professor at the Interdisciplinary Center Herzelia (IDC) Parkinson's Taking Mannitol since Oct 27, 2016 JOIN US Slide FIGHTING PARKINSON'S DISEASE Avihu Ben-Nun, Major General (retired), the 11th commander of the Israeli Air Force between 1987 and 1992

“We have the opportunity and the reason for hope. So now is the time for You to join us.”
Parkinson's Taking Mannitol since Aug 31, 2016 JOIN US



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