FREQUENTLY ASKED QUESTIONS (FAQ)


CliniCrowd has no relationship with Cherry sellers. It can be freely purchased.

After you fill out the initial registry, you will be directed to a page that includes, among other information, a list of suppliers that were recommended by other participants like you.

It is recommended to save and print that page.

CliniCrowd has no relationship with Mannitol manufactures. It can be freely purchased.

After you fill out the initial registry, you will be directed to a page that includes, among other information, a list of suppliers that were recommended by other participants like you.

It is recommended to save and print that page.

Please Note – CliniCrowd does not provide or sell Cherries and does not have any financial relationship with Cherry sellers.

Eating cherries in their many forms and varieties, like canned, frozen, raw, cooked, tart, pill, sweet and black are thought of been beneficial to treat gout. Consuming dried cherries, fresh or juiced are all good.

After you fill out the initial registry, you will be directed to a page that includes, among other information, dosage, regimen and cherries type information

Please Note – CliniCrowd does not manufacture, provide or sell Cinnamon and does not have any financial relationship with Cinnamon manufactures.

Here are a few points that should be considered when you buy Cinnamon:

  1. The label indicates that the Cinnamon is good for human consumption.
  2. It’s recommended to check the supplier/manufacturer has positive reviews.
  3. Buy the original bark rather than the grinded spice and grind it yourself, or have it done in front of you.
  4. Ceylon Cinnamon is preferred.
  5. Follow the preparation instructions to which you will be directed following the Alzheimer’s initial registry.
  6. Don’t consume more than the recommended dosage.

According to the research the dosage is calculated per body weight.

Once you submit the Gout initial registry, you will be directed to a page that includes, among other information, the recommended dosage.
It is recommended to save and print that page.
In case you already fill out the registry and cannot find the relevant dosage – kindly contact as – at the following link– and choose “Other” under “How Can we help you?”

According to the research the dosage is calculated per body weight.

Once you submit the Parkinson’s initial registry, you will be directed to a page that includes, among other information, a table of dosage per weight.
It is recommended to save and print that page.
In case you already filled-out the registry and cannot find the relevant dosage table – kindly contact us at contact us and choose “Other” under “How Can we help you?”

The research dosage is translated to human dosage.
It is important to remember – as the disease is expressed in different ways per person, it makes sense that “best fit” of cherries will be different as well – it is important to try and listen to your body in a way that is most suitable for you.
The wisdom of the crowd is built from many individuals and details.
You have the opportunity to be a part of this community and to share your knowledge and insights.

Once you submit the Gout initial registry, you will be directed to a page that includes, among other information, the recommended dosage

Calories Quickly Accumulate

It sounds strange to say that a healthy fruit may provide too many calories, but it’s true if you eat an excessive number of cherries. One cup of sweet cherries contains 97 calories, which is low enough to make this serving size a good choice for snacks. What seems like a reasonable number of calories will quickly add up, however, if you don’t pay attention to the amount you eat. Be sure to include cherries as part of your regular daily calories. Adding 97 calories on top of a diet that already fills your calorie needs will contribute to weight gain.

Excess Fiber Causes Side Effects

One cup of cherries has 3 grams of fiber, or 12 percent of the daily value, based on eating 2,000 calories a day. If you eat a large portion of cherries, the amount of fiber you’ll consume can cause side effects such as bloating, gas and diarrhea. This is more likely to happen if you’re not used to eating fiber. You can reduce the risk of side effects by increasing fiber gradually, which gives your digestive tract time to adjust. Women should consume 25 grams of fiber daily, while men need 38 grams, according to the Institute of Medicine.

Carb Consumption Too High

The U.S. Department of Agriculture recommends consuming 1.5 cups to 2 cups of fruit every day. If you use cherries to meet that goal, or if you simply eat a lot of cherries, you’ll also consume a significant amount of carbohydrates. Two cups of cherries contain 50 grams of total carbohydrates, or 17 percent of the daily value for carbs, based on a 2,000-calorie-a-day diet. The carbs in cherries consist of fiber and sugar. In addition to consuming double the fiber, eating 2 cups of cherries means you’ll consume 40 grams of sugar. The fiber helps prevent a spike in blood sugar, but if you get more sugar than your body needs for energy, it will be stored as fat.

Each registry is important. Only with your help we can become a big enough community to make an impact, so be sure to fill out the follow-up registry once a month.

According to the research the dosage is calculated per body weight.
From the collected registries so far, we know that there are some people who take Mannitol less than the calculated dosage and some take more than the calculated dosage.
It is important to remember- as the disease is expressed in each person in a different way and in different symptoms, it makes sense that “best fit” of Mannitol will be different as well – it is important to try and listen to your body in a way that is most suitable for you.
The wisdom of the crowd is built from many individuals and details.
You have the opportunity to be a part of this community and to share your knowledge and insights.
Each registry is important. Only with your help we can become a big enough community to make an impact, so be sure to fill out the follow-up registry once a month.

From the collected registries so far, we know that there are people who take Mannitol in the morning, and there are those that take Mannitol in the evening.

Some people split the Mannitol dosage for morning and evening and some prefer to take along with other medications – there is no trend.

More than that, it is important to remember – as the disease is expressed in each person in a different way and in different symptoms, it makes sense that taking Mannitol will be different as well.

Some might find it better in the morning and some in the evening.

It is important to try and listen to your body in a way that is most suitable for you.

The wisdom of the crowd is built from many individuals and details.

You have the opportunity to be a part of this community and to share your knowledge and insights.

Each registry is important. Only with your help we can become the crowd, so be sure to fill out the follow-up registry once a month.

No two people with Alzheimer’s have the same symptoms and same effectiveness of treatments.
Same for Cinnamon, it affects each person differently.

We need many participants to report on a monthly-basis, in order to reflect solid data.

The research suggests that Cinnamon may prevent the deterioration of Alzheimer’s in animals and even improve its symptoms, it is yet to be proven in humans.

Filling out the Alzheimer Follow Up registries on a regular basis, allows participants to share and validate the efficacy of Cinnamon.
In turn, we will share the collected data allowing the individual participant to learn about Cinnamon efficacy for Alzheimer’s.

From the collected registries so far, we know that there are people who take Mannitol with meal or with beverage.
As the disease is expressed in each person in a different way and in different symptoms, it makes sense that taking Mannitol will be different as well. Some might find it better with meal and for some it could be better before or after a meal or even just with beverage. it is important to try and listen to your body and see what is most suitable for you.
The wisdom of the crowd is built from many individuals and details.
You have an opportunity to be a part of this community and to share your knowledge and insights.
Each registry is important. Only with your help we can become the crowd, so be sure to fill out the follow-up registry once a month.

Currently we don’t have any information about contra-indication of Cinnamon with other medications/supplements.
Disclaimer – CliniCrowd does not provide medical advice. For medical advice regarding how to manage your disease, please consult your physician.

Cinnamon is not known to contra indicate any of the above, on the contrary, there is a recent study, published Nov 2017 in the Xenobiotica Journal and another study published April 2015, in the Journal of Traditional and Complementary Medicine that claim that Cinnamon may have an alleviating effect on diabetes.

Disclaimer – CliniCrowd does not provide medical advice. For medical advice regarding Cinnamon and heart disease, high blood pressure or any other disease please consult with your physician.

Yes. Cinnamon, in the required dosage, is considered as safe.
FDA has determined Cinnamon to be GRAS (Generally Recognized As Safe) as a food additive – see FDA link

Precaution:
While Cinnamon is commonly regarded as a healthy, natural spice and delicious condiment, occasional side effects may occur when taking it, and allergies can happen.
If you are allergic to Cinnamon, it is highly recommended that you refrain from taking it in any form.
Ceylon and Cassia Cinnamon both contain Coumarin. When Coumarin is consumed in extremely high doses, it may cause some dangerous side effects. Ceylon Cinnamon contains far less Coumarin than Cassia Cinnamon.

We recommend to follow preparation instructions with Ceylon Cinnamon at recommended doses.
However, as a spice, it would be unusual for someone to consume large enough amounts of either type of Cinnamon to cause concern.
Always talk to your doctor before making significant changes to your diet.

Yes. Cinnamon, in the required dosage, is considered as safe.

FDA has determined Cinnamon to be GRAS (Generally Recognized As Safe) as a food additive – see FDA link

Precaution:
While Cinnamon is commonly regarded as a healthy, natural spice and delicious condiment, occasional side effects may occur when taking it, and allergies can happen.
If you are allergic to Cinnamon, it is highly recommended that you refrain from taking it in any form.
Ceylon and Cassia Cinnamon both contain Coumarin. When Coumarin is consumed in extremely high doses, it may cause some dangerous side effects. Ceylon Cinnamon contains far less Coumarin than Cassia Cinnamon.

We recommend to follow preparation instructions with Ceylon Cinnamon at recommended doses.
However, as a spice, it would be unusual for someone to consume large enough amounts of either type of Cinnamon to cause concern.
Always talk to your doctor before making significant changes to your diet.

According to a study, funded in part by the Parkinson’s Disease Foundation, in the June 14 issue of The Journal of Biological Chemistry, the compound Mannitol, not only improved PD-like symptoms in fruit flies, but also reduced harmful levels of Alpha-Synuclein (the hallmark of PD) in the brains of fruit flies and mice, that were genetically-engineered to express the PD human gene.

Researchers took interest in Mannitol since, when Mannitol is given as an injection, it has two unique properties. First, it can cross the blood brain barrier (meaning the drug can reach the brain). Second, it is able to stop some proteins in the body from clumping together, which is interesting in light of the fact that clumps of the protein Alpha-Synuclein are a well-known sign of Parkinson’s disease.

Scientists suggest that Mannitol appears to function as a chemical chaperone, meaning that the sweetener stabilizes proteins like Alpha Synuclein and prevents them from inappropriately clumping together.

Knowing these properties, Daniel Segal, Ph.D., and Ehud Gazit, Ph.D., at Tel Aviv University, in Israel, wondered whether Mannitol might be helpful for Parkinson’s disease. They examined Mannitol in the lab and in fruit flies and mice. They studied whether Mannitol can improve the motor symptoms of fruit flies with PD-like symptoms, and whether it can change the levels of Alpha-Synuclein in all three experiments.

  • In the test tube, Mannitol prevented Alpha-Synuclein protein from clumping into the Lewy bodies that form in the brains of people with PD.
  • In the fruit fly model of PD, Mannitol restored the flies’ normal movements, for example their ability to climb up test tubes.
  • In the same flies, Mannitol reduced Alpha-Synuclein clumps by 70%.
  • In the PD mice model, Mannitol injections reduced Alpha-Synuclein clumps in several areas of the brain involved with classic PD and protected dopamine-producing neurons, the brain cells affected in PD.

This study demonstrates the potential ability of Mannitol to prevent Alpha-Synuclein clumping that takes place in PD. The results indicate that Mannitol should be studied for its potential to treat PD

Cinnamon is a spice that can be purchased from different manufacturers. It has been available and used in the food industry for ages. There is no commercial incentive for pharma companies to invest in its research or in promoting it. Research publications are not easily accessible to the general public, although it was published in several websites (in addition to research publications). See:

Brain Food Essentials: CINNAMON

Cinnamon May Be Fragrant Medicine For The Brain, 2016

Why Cinnamon May Hold Secrets to Alzheimer’s Prevention, 2014

Memory loss that disrupts daily life, Challenges in planning or solving problems, Difficulty completing familiar tasks at home, at work or at leisure, Confusion with time or place, Trouble understanding visual images and spatial relationships, New problems with words in speaking or writing, Misplacing things and losing the ability to retrace steps, Decreased or poor judgment, Withdrawal from work or social activities, Changes in mood and personality.

Bladder and bowel problems, eye problems, falls and dizziness, fatigue, freezing, pain, restless legs syndrome, skin and sweating problems, sleep problems, speech and communication problems and swallowing problems. Loss of sense of smell is one of the earliest symptoms for many (not all) people living with Parkinson’s. Sometimes it appears years before the diagnosis.

While there is currently no cure for Alzheimer’s, there are a range of drugs that can be used to manage the symptoms of the condition.

  • Donepezil (Aricept) is approved to treat all stages of Alzheimer’s.
  • Rivastigmine (Exelon) is approved to treat mild to moderate Alzheimer’s.
  • Galantamine (Razadyne) is approved to treat mild to moderate Alzheimer’s.
  • Potential mental health impacts may be anxiety, dementia, depression, hallucinations and delusions and memory problems.

    CliniCrowd is a social impact company

    CliniCrowd searches for nutriments that are safe for human consumption, recognized by FDA as GRAS (Generally Recognized as Safe), and have scientific evidence (in research papers) to be used to hopefully enhance wellbeing and possibly impact symptoms of diseases. CliniCrowd encourages those who would like to try to take the nutriment for the specific disease to report into the CliniCrowd platform, which is a web-based registry platform. In turn, CliniCrowd will present its findings as is to the crowd.

    Patients voluntarily register for the registry and enter their health information, purchase and administer the products themselves, and enter treatment outcome data on the website.
    Disclaimer – CliniCrowd does not provide medical advice. For medical advice regarding how to manage your Parkinson’s disease, please consult your doctor

    Alzheimer’s is a complex condition that affects different people in different ways. Each person living with Alzheimer’s has its own individual experience. Symptoms differ from one person to the other. No two people with Alzheimer’s have the same symptoms and the same effectiveness of the treatment.

    It’s important to remember that everyone’s experience of Alzheimer’s is different. Not everyone will experience all symptoms.

    The order in which symptoms appear and the way symptoms progress also varies from one to another.

    You’re welcome to share information as that you’re comfortable with. Here’s what would be visible in the Web site: charts featuring information you and others in the community share about condition such as: treatments, drugs, and symptoms, demographic information such as: age, gender and location (country). In your personal secured zone the platform will present specific information related to you based on the follow-up registers, you have been completing, such as; your improvement chart.

    We follow the best methods in security. We also use state of the art firewalls for our servers, and our systems have been developed to prevent the most common security vulnerabilities. For secure browsing, we use SSL.

    Understanding privacy is important. Our platform can only work if we build trust with our patients and members. Without this trust we would not be able to accomplish our mission to explore new types of remedy by the crowd for the crowd. Privacy is also a legal issue and we have worked hard to develop a good policy that is also easy to read and understand. Please review our privacy policy carefully here.

    Thank you for filling out the Alzheimer initial registry and joining our community!

    Next step: keep filling out the Alzheimer follow-up registry on a monthly basis.

    Our platform collects data from people who want to better manage their medical condition.
    By using our registries, you will be able to learn valuable information such as Cinnamon efficacy and great insights regarding Alzheimer’s from the wisdom of the crowd. Moreover, by continuously filling out the follow-up registry, you will able to enjoy personal reports whether you are taking Cinnamon or not.

    With your help, our goal is to share information and insights once we will collect sufficient data from the crowd. This will take some time since responsible insights can be achieved only once substantial amount of registries are obtained (both number of subjects and number of follow-ups). Some information will be presented only for people who registered to our website. Additional information, insights and personal reports will be available only for participates in the registry.

    Cherries contain fructose. 10 sweet cherries or 1 cup of sour cherries contain about 4 grams of fructose. Subjects who live with Gout should limit the fructose/sugar intake to below 25 grams a day.

    The U.S. Department of Agriculture recommends consuming 1.5 cups to 2 cups of fruit every day. If you use cherries to meet that goal, or if you simply eat a lot of cherries, you’ll also consume a significant amount of carbohydrates. Two cups of cherries contain 50 grams of total carbohydrates, or 17 percent of the daily value for carbs, based on a 2,000-calorie-a-day diet. The carbs in cherries consist of fiber and sugar. In addition to consuming double the fiber, eating 2 cups of cherries means you’ll consume 40 grams of sugar. The fiber helps prevent a spike in blood sugar, but if you get more sugar than your body needs for energy, it will be stored as fat.

    It is recommended to save and print that page.

    CliniCrowd has no relationship with Cinnamon manufactures. Once you fill out the Alzheimer initial registry you will be directed to a page that includes, among other information, recommended stores for purchasing cinnamon as well as preparation instructions and dosage.

    It is recommended to save and print that page.

    Please Note – CliniCrowd does not manufacture, provide or sell Mannitol and does not have any financial relationship with Mannitol manufactures.

    Here are a few points that should be considered when you buy Mannitol:

    1. The label indicates that the Mannitol is good for human consumption (as a sweetener).
    2. The label includes a FDA notice that when taking over 20 grams a day there might be side effects such as a laxative effect.
    3. It’s recommended to check the supplier/manufacturer has positive reviews.
    4. It’s recommended to check that the supplier/manufacturer works according to his territory regulation and preferable also according to USA and/or EU regulation.
    5. Purity of Mannitol –  is high (above 99%).
    6. Pay attention that you purchase or examine the above regarding MANNITOL and not MALTITOL.

    AD – initial
    MCI – initial
    AD – follow-up
    MCI – follow-up

    The chance of suffering any type of side effect from eating cherries is slim, as long as you’re not allergic. But overconsumption raises some red flags. On the positive side, cherries provide iron, potassium, vitamin C and antioxidant phytochemicals. They’re also good sources of fiber and carbohydrates, so they can boost your energy while adding beneficial fiber to your diet. Cherries contain enough fiber and carbs to cause problems if you eat too many, however.

    Note about Allergies

    Cherries contain proteins that cause allergies in some people. If you’re allergic to cherries, you can’t eat any amount without suffering a reaction, which may include shortness of breath, swallowing problems, hives, nausea or diarrhea. Consuming either a few cherries or a large amount can result in life-threatening symptoms such as difficulty breathing and low blood pressure. People who are allergic to grapes, apples, peaches, apricots or hazelnuts may also have an allergy to cherries, reports the American Academy of Allergy, Asthma and Immunology.

    Don’t freak out if you accidentally swallow a cherry pit they’re rarely poisonous when eaten whole but don’t eat a broken pit. Because aside from tasting really bitter and generally being impossible to chew, the stones of certain stone fruits, like cherries, contain cyanogenic compounds science talk for “stuff that your body can turn into cyanide.”

    Hydrogen cyanide is lethal at about 1.52 milligrams per kilogram, meaning that it takes little more than 0.1 grams of the toxin to dispatch a 150-pound human. A single cherry yields roughly 0.17 grams of lethal cyanide per gram of seed, so depending on the size of the kernel, ingesting just one or two freshly crushed pits can lead to death.

    Please refer to the preparation instructions. The information will be available once you submit the Alzheimer’s initial registry.
    It is recommended to save and print that page.
    In case you already filled-out the registry and cannot find the relevant preparation method and dosage – kindly contact us at contact us and choose “Other” under “How Can we help you?”

    The research dosage is translated to human dosage.
    It is important to remember – as the disease is expressed in different ways per person, it makes sense that “best fit” of Cinnamon will be different as well – it is important to try and listen to your body in a way that is most suitable for you.
    The wisdom of the crowd is built from many individuals and details.
    You have the opportunity to be a part of this community and to share your knowledge and insights.
    Each registry is important. Only with your help we can become a big enough community to make an impact, so be sure to fill out the Alzheimer follow-up registry once a month.

    From what we know so far people split the Cinnamon dosage and take cinnamon both in the morning and in the evening.

    It is important to remember – as the disease is expressed in each person in a different way, it makes sense that taking Cinnamon will be different as well.

    It is important to try and listen to your body in a way that is most suitable for you.

    The wisdom of the crowd is built from many individuals and details.

    You have the opportunity to be a part of this community and to share your knowledge and insights.

    Each registry is important. Only with your help we can become the crowd, so be sure to fill out the follow-up registry once a month.

    No two people with Parkinson’s have the same symptoms and same effectiveness of treatments.
    Same for Mannitol, it affects each person differently.

    Research shows that the Mannitol helps to prevent the deterioration of PD disease, in addition some participants report the following:

    • After 18-30 days with Mannitol they feel a change
    • After 30-60 days some observed a slight decrease in symptom improvements and even some regression
    • After 90 days they report continuous improvement

    Please note – that this is preliminary data. There are participants that experience changes after a few months, and some that may not experience any change in symptoms, however, their change will be expressed by no deterioration of their disease. Some may not experience any change in symptoms but receive feedback from the people around them.

    Therefore we need more participants to report on a monthly-basis, in order to reflect more solid data.

    The research suggests that Mannitol might prevent the deterioration of PD.
    Some of the participants, that have been taking Mannitol, report that there is some improvement in their symptoms.

    Filling out the Follow Up registries on a regular basis, allows participants to share and validate the efficacy of Mannitol.
    In turn, we will share the collected data allowing the individual participant to learn about Mannitol efficacy for Parkinson’s – all based on the wisdom of the crowd.

    The cinnamon extract is a beverage, therefore there is no need to take it with any other food.
    It However, it is important to try and listen to your body and see what is most suitable for you.

    The wisdom of the crowd is built from many individuals and details.
    You have an opportunity to be a part of this community and share your knowledge and insights.
    Each registry is important. Only with your help we can become the crowd, so be sure to fill out the Alzheimer follow-up registry once a month.

    Currently we don’t have any information about contra-indication of Mannitol with other medications/supplements.
    Disclaimer – CliniCrowd does not provide medical advice. For medical advice regarding how to manage your disease, please consult your physician.

    According to the FDA, Mannitol does not cause a sudden increase in blood glucose and/or insulin. Regarding heart disease or high blood pressure there is no reference in the FDA document.
    Disclaimer – CliniCrowd does not provide medical advice. For medical advice regarding Mannitol and heart disease, high blood pressure or any other disease please consult with your physician.

    Yes. Mannitol, in the required dose, is considered as safe.
    FDA has determined Mannitol to be GRAS (Generally Recognized As Safe) as a food additive – see FDA link  and EFSA link.

    The side effect can be – bloating.

    Above 20gr (0.71 ounces) per day – may have a laxative effect.

    Other side effects that are listed on the Internet refer to higher dosage used for I.V. treatment.

    As of today there is increasing evidence that accumulation of soluble oligomeric assemblies of β-amyloid polypeptide (Aβ) play a key role in Alzheimer’s Disease (AD) pathology. Specifically, 56 kDa oligomeric species were shown to be correlated with impaired cognitive function in AD mice model. Several reports have documented the inhibition of Aβ plaque formation by compounds from natural sources. Yet, evidence for the ability of common edible elements to modulate Aβ oligomerization remains an unmet challenge. In a research by Prof Michal Ovadia, at Tel Aviv University, in Israel, published in the Jan 2011 issue of PLOS One, a natural substance, based on cinnamon extract (CEppt), was identified. This extract was found tomarkedly inhibit the formation of toxic Aβ oligomers and prevents the toxicity of Aβ on neuronal PC12 cells.

    When administered to an AD fly model, CEppt rectified their reduced longevity, fully recovered their locomotion defects and totally abolished tetrameric species of Aβ in their brain.

    Furthermore, oral administration of CEppt to an aggressive AD transgenic mice model led to marked decrease in 56 kDa Aβ oligomers, reduction of plaques and improvement in cognitive behavior. The results present a novel prophylactic approach for inhibition of toxic oligomeric Aβ species formation in AD through the utilization of a compound that is currently in use in human diet.

    According to another study: Cinnamon Extract Inhibits Tau Aggregation Associated with Alzheimer’s Disease In Vitro” published in the July 2009 issue of the Journal of Alzheimer’s Disease, an aqueous extract of Ceylon cinnamon (C. zeylanicum) is found to inhibit tau aggregation and filament formation, hallmarks of Alzheimer’s disease (AD). The extract can also promote complete disassembly of recombinant tau filaments and cause substantial alteration of the morphology of paired-helical filaments isolated from AD brain. Cinnamon extract (CE) was not deleterious to the normal cellular function of tau, namely the assembly of free tubulin into microtubules. An A-linked proanthocyanidin trimer molecule was purified from the extract and shown to contain a significant proportion of the inhibitory activity. Treatment with polyvinylpyrolidone effectively depleted all proanthocyanidins from the extract solution and removed the majority, but not all, of the inhibitory activity. The remainder inhibitory activity could be attributed to cinnamaldehyde. This research shows that compounds endogenous to cinnamon may be beneficial to AD themselves or may guide the discovery of other potential therapeutics if their mechanisms of action can be discerned.

    Mannitol is a low calorie sweetener (1.6 calories per gram).
    It is found in plants, fungi, bacteria and algae.
    Manitol is produced mainly synthetically and can be found in –
    • pharmaceutical industry – intravenous  injection of Mannitol is used  for example – to reduce intracranial pressure
    • food industry – as a substitute for sugar (sweetener) in chewing gum, candy, beverages, foods and pastries
    The composition and safety precautions for use are identical to those found in nature

    According to the Food and Drug Administration (FDA) Mannitol does not increase sugar levels.

    Mannitol is a sweetener/low calorie sugar substitute that can be purchased from different manufacturers. It has been available and used in the food industry for several decades. Mannitol is not patentable and there is no commercial incentive for pharma companies to invest in its research or in promoting the Mannitol.

    Tremor (shaking), slowness of movement, rigidity (stiffness). Tremor (shaking) is one of the common symptoms of Parkinson’s, alongside slowness of movement and rigidity (stiffness). Not everyone will experience all of these symptoms.

    For some people, a tremor can be the first sign of Parkinson’s. However, having a tremor doesn’t always mean you have Parkinson’s as it can be caused by other conditions. Not everyone who has Parkinson’s will have a tremor.

    While there is currently no cure for Parkinson’s, there are a range of drugs that can be used to manage the symptoms of the condition.

    These are the main types of drugs used to treat Parkinson’s: Levodopa, Dopamine agonists, MAO-B inhibitors, COMT inhibitors, Glutamate antagonist and Anticholinergics.

    The symptoms of Parkinson’s happen when the level of dopamine, a chemical messenger in your brain, becomes too low. This is because many of the brain cells that produce dopamine have died or are dying.

    Without enough dopamine, your movement slows down and it may take longer to do things. You may also lack co-ordination or your hands or other body parts may shake. Each type of drug works in a different way to alleviate this problem.

    Most of the drugs work to help the movement symptoms of Parkinson’s either by: increasing the amount of Dopamine in the brain or stimulating the parts of the sense brain where Dopamine works, or blocking the action of other factors (enzymes) that break the down Dopamine.

    Depression, Fall-related injuries, Immobility, Malnutrition and dehydration, Pneumonia, Urinary tract infections.

    There are 4 types of registries for Parkinson’s (PD):

    1. PD Initial –
      Parkinson’s initial registry is our way to collect baseline information regarding people living with Parkinson’s.
      Patients voluntarily register for the registry and enter their health information.
      Click here to access the registry.
    2. PD Follow-up –
      Parkinson’s follow-up registry is our way to continue collecting information regarding people living with Parkinson’s.
      We recommend to fill out the registry on a monthly basis. You can add a reminder to your calendar.
      Click here to access the registry.
    3. PD Prevention Initial –
      Parkinson’s initial registry is our way to collect baseline information regarding people without Parkinson’s, who want to prevent it (such as healthy people, people with Parkinson’s in the family, genetically diagnosed to have one of the PD/Gaucher genes). Patients voluntarily register for the registry and enter their health information.
      Click here to access the registry.
    4. PD Prevention Follow-up –
      Parkinson’s follow-up registry is our way to continue collecting information regarding people who want to prevent Parkinson’s.
      We recommend to fill out the registry on a quarterly basis. You can add a reminder to your calendar.
      Click here to access the registry.

    Parkinson’s is a complex condition that affects different people in different ways. Each person living with Parkinson’s has its own individual experience. Symptoms differ from one person to the other. No two people with Parkinson’s have the same symptoms and the same effectiveness of the treatment.

    The symptoms most often associated with Parkinson’s affect movement. These are often called motor symptoms. However, there are other symptoms that aren’t related to movement, such as pain and depression. These are known as non-motor symptoms. The common symptoms that people with Parkinson’s may get are listed below.

    It’s important to remember that everyone’s experience of Parkinson’s is different. Not everyone will experience all of these symptoms.

    The order in which symptoms appear and the way symptoms progress also varies from one to another.

    The reports only reflect data that has been shared by the crowd. They cannot be guaranteed to be accurate, and they are not intended to represent complete information about a nutriment, symptom, or condition.
    Disclaimer – CliniCrowd does not provide medical advice. For medical advice regarding how to manage your disease, please consult your doctor

    You can report these changes in the follow up registry. Please report regularly or once there is a change in medication / symptoms / change of nutriment dosage etc.

    When you sign-up for CliniCrowd, you can be identified as a caregiver or relative of the participant (see privacy policy). This means that you’ll enter data as if you’re the patient=participant, instead of yourself. However, the privacy policy and consent refer to the patient with the specific condition.

    Participating in the CliniCrowd registry is your choice and is completely voluntary.
    You can decide to stop at any time.
    Simply contact the CliniCrowd Registry coordinator, and all of your data will be removed from the CliniCrowd Database.
    Un-identifiable data shared will also be removed. However, un-identifiable data cannot be retrieved from researchers that have already accessed it prior to your request for removal.
    CliniCrowd may withdraw you from the registry if circumstances arise which warrant doing so, even if you would like to continue.
    We will tell you about new information or changes in the CliniCrowd Registry that may affect your willingness to continue in the study.

    Disclaimer
    CliniCrowd does not provide medical advice. For medical advice regarding how to manage your disease, please consult your physician.

    Thank you for filling out the registry and joining our community!

    Next step: keep filling out the follow-up registry on a monthly basis.

    Our platform collects data from people who want to better manage their medical condition.
    By using our registries, you will be able to learn valuable information such as Mannitol efficacy and great insights regarding Parkinson’s from the wisdom of the crowd. Moreover, by continuously filling out the follow-up registry, you will able to enjoy personal reports whether you are taking Mannitol or not.

    With your help, our goal is to share information and insights once we will collect sufficient data from the crowd. This will take some time since responsible insights can be achieved only once substantial amount of registries are obtained (both number of subjects and number of follow-ups). Some information will be presented only for people who registered to our website. Additional information, insights and personal reports will be available only for participates in the registry.