CliniCrowd Alzheimer’s Prevention registry is driven by pre-clinical studies conducted by several researchers, leading among them by Professor Ovadia at Tel Aviv University in Israel. See publication.
Alzheimer’s disease has no known cure, but its symptoms can be treated in various ways that can increase the quality of life in patients.
Alzheimer’s disease (AD) pathology is characterized by an accumulation of soluble oligomeric assemblies of a protein called amyloid-beta (Aβ) around brain cells. It is assumed that the main damage arises from the plaque deposits of Amyloid-beta fibrils as soluble oligomeric assemblies. This protein was shown to be correlated with impaired cognitive function.
Another protein was found in the brain cells, called tau, which is also linked to memory loss and other deficits found in Alzheimer’s patients.
Cinnamon has many described health benefits. Among them are improvement of Alzheimer’s symptoms and or along with antioxidant, anticholesterol, antidiabetes, and antibacterial properties.
Cinnamon was found by the FDA to be generally recognized as safe (GRAS) food additive, see link to FDA site.
In pre-clinical studies, cinnamon markedly inhibited the formation of toxic amyloid- beta (Aβ) oligomers, which is the protein found in the brain of Alzheimer’s patients.
Furthermore, oral administration of cinnamon extract given to animals with Alzheimer’s led to marked decrease in amyloid-beta in their brain, reduction of plaques and improvement in cognitive behavior. See publication.
An aqueous extract of cinnamon was found to inhibit tau aggregation and filament formation See publication,
Both Aβ and TAU are hallmarks of the Alzheimer’s disease.