Do you have the Parkinson’s gene ?

Any close relative with Parkinson’s ?

Do you want to try to prevent Parkinson’s ?

JOIN REGISTRY

Parkinson’s Prevention

What Do We Offer ?

Crowd sourcing platform that explores and validates scientifically-based, natural, safe and easily-accessible nutriments that have a potential to prevent Parkinson’s disease

Click below to enter the PD PREVENTION registry, both 1st time and returning participants

JOIN REGISTRY

Why You ?

Individuals have the right to know, access and explore nutriments to prevent various ailments. To date pharma companies have no financial incentive to investigate or promote Mannitol for the prevention of Parkinson’s

What Are The Benefits ?

Awareness and insights gained through ongoing, on-line reporting by the community motivated to prevent Parkinson’s disease

PARKINSON PREVENTION AND MANNITOL SCIENTIFIC-BASED DATA

Parkinson’s disease (PD) is characterized by degeneration and loss of neurons, particularly those crucial for coordination of movements. Studies have shown that by the time the symptoms appear, people with Parkinson’s have lost 60% to 80% of their dopamine producing cells. According to the Michael J. Fox Foundation, the degeneration and loss of neurons is the pathological hallmark of Parkinson’s.

Alpha synuclein is an abundant protein in the brain especially in the presynaptic terminal of neurons. It plays a role in maintaining vesicles for the neurotransmitters in the nerve endings. There has been significant research in the areas of preventing excess alpha synuclein formation or clumping and disruption of the already existing clumps.

According to NIH Genetics Home Reference, there are genes known to predispose for Parkinson’s: Approximately 15% of people with Parkinson’s disease have a family history of this disorder. Familial cases of Parkinson’s disease can be caused by mutations in the LRRK2, PARK2, PARK7, DJ-1, PINK1, SNCA, or TMEM230 gene, or by alterations in genes that have not been identified. Mutations in some of these genes may also play a role in cases that appear to be sporadic (not inherited) alterations in certain genes, including GBA (associated with Gaucher disease, see relationship between Gaucher disease and Parkinson’s disease) and UCHL1, which do not cause Parkinson’s disease but appear to modify the risk of developing the condition in some families. Variations in other genes that have not been identified probably also contribute to Parkinson’s disease risk.

Mannitol, a common low calorie sweetener, determined by the FDA to be generally recognized as safe (GRAS) food additive – see link to FDA site and link to EFSA site – has shown that it can prevent alpha synuclein clumping in pre-clinical studies conducted by Professor Daniel Segal and Professor Ehud Gazit at Tel Aviv University in Israel, in collaboration with Professor Eliezer Masliah at University of California, San Diego. Their publication, showed that in the test tube Mannitol was effective in preventing formation of alpha-synuclein aggregates, which are known to cause Parkinson. Furthermore, they used transgenic fruit-flies, which were genetically engineered to have alpha-synuclein aggregates in their brain, and fed them with Mannitol starting at early stages of their life cycle and throughout adulthood.  This resulted in markedly less aggregates of alpha-synuclein in the brains of the flies, compared with flies that did not receive Mannitol, and was accompanied by significant amelioration of their motor deficits.

Considering together, these results suggest that Mannitol may have a preventive effect on Parkinson’s.

The researchers also examined the effect of Mannitol in Parkinson’s mice model. Note, Mannitol was administered to the mice when they already began to develop alpha-synuclein aggregates, and not before.  Therefore, the mice experiments were not designed specifically to test Parkinson’s prevention. Nevertheless, the encouraging results from the mice experiments do suggest that Mannitol may have prevented further build-up and promoted clearance of the aggregates, thereby accounting for the observed reduction in brain pathology of the Mannitol treated mice compared with untreated counterparts.

Consider joining CliniCrowd’s Prevention Registry if you are healthy and:

  • Were tested positive genetically to carry a gene causing Parkinson’s, or
  • Tested positive genetically to carry a recessive gene for Gauche, or
  • Have close relatives living with Parkinson’s, or
  • Have close relatives living with Gaucher

and decided to take Mannitol as a preventive nutriment.

For further information about Mannitol and Parkinson’s register below. Registering and reporting on your condition every 2 months (follow-up registry), will entitle you to an annual report reflecting your data as well as cumulative data and findings for the entire community.

With your assistance and further research, we hope we can present relevant data regarding Mannitol and its ability to prevent Parkinson’s.

Click below to enter the prevention registry, both 1st time and returning participants

JOIN REGISTRY

THE CLINICROWD PLATFORM

The International community has the right to know !

We’ve launched a broad, on-line, protected platform that collects, analyzes and generates the communities’ verified experiences with researched Nutriments.

This platform will help fast track validating Nutriments as remedies.

The Platform enables the people that would like to see if they can prevent Parkinson’s to easily access and use our proprietary Parkinson‘s Prevention registry and expanded applications, allowing participants to monitor, share and validate the efficacy of Mannitol.

The Platform will, in turn, provide analytics and shared insights.

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How Does It Work ?

VERIFY we identify and assess scientific data relevant to Parkinson’s prevention
BELIEVE we trust the power and wisdom of the crowd to influence others that may want to try and prevent Parkinson’s
EXPLORE we collect ongoing data and analyze the impact of Mannitol on prevention of Parkinson’s
SHARE we protect unidentified data and share insights with our participants (see privacy policy)
VALIDATE we corroborate the big-data validating Mannitol as an prevention solution

We intend to raise Awareness, gain Acceptance and increase Adoption of Mannitol as an option.

The only way to do this is By the Crowd for the Crowd.

Join the Registry Today and Help Us Help you !

Click below to enter registry, both 1st time and returning participants

JOIN REGISTRY

WHAT’S IN IT FOR ME ?

1.       Share my experiences while receiving ongoing reports regarding my health and status

2.       Benefit from analytics and insights based on accumulated data from the Crowd

3.       Gain access to a platform to fast track Awareness, Acceptance and Adoption of a potentially new and safe prevention remedy

4.       Be a part of a community whose common goal is to prevent Parkinson’s

5.       Take an active role in creating change that will have a positive impact throughout the world

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PARKINSON’S  EXPERIENCE